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KMID : 0043319970200030234
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Archives of Pharmacal Research
1997 Volume.20 No. 3 p.234 ~ p.238
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Suppressive Effects of Triterpenoids on CINC-1 Induction in Interleukin-1{\betha}-stimulated rat fibroblast NRK-49F cells
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Ha Joo-Young
Min Kyung-Rak
Kang She-Hoon
Kim Ju-Sun
Lee Gyeong-Im
Kang Sam-Sik
Kim Young-Soo
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Abstract
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CINC-1 is a member of chemokine family with chemotactic and activating properties to neutrophils. CINC-1 induction in IL--stimulated rat fibroblast NRK-49F cells was quantitated by a sensitive ELISA. CINC-1 production was increased up to 135 ng/ml from basal 2-6 ng/ml by stimulation with IL-.Steroidal anti-inflammatory drugs including dexamethasone and prednisolone exhibited potent suppressive effects on IL---induced CINC-1 production. Among 39 kinds of natural triterpenoids tested, acacigenin B exhibited the highest suppressive effects with about to be 50% of inhibition on the CINC-1 induction. The suppressive potency of acacigenin B on IL-induced CINC-1 production was about 10-fold less than that of the steroidal anti-inflammatory drugs
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KEYWORD
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CINC-1 induction, IL-β-stimulated NRK-49F cells, Triterpenoids, Anti-inflammatory drugs, ELISA
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